US CDC advisory committee recommends Pfizer and Moderna vaccines rather than Janssen

The U.S. Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) recommended vaccination with Hwaazawa Moderna vaccine rather than Janssen vaccine. ACIP, an expert panel of the CDC, held an emergency meeting on the 16th (local time) to choose the mRNA vaccine (Pfizer and Moderna) rather than the Janssen vaccine because of the risk of thrombocytopenic thrombosis (TTS), which causes blood clots in the brain and intestines. The recommendation of the recommendation was unanimously voted on by 15-0.

Platelets play a role in coagulating blood to form clots, and if there are too many clots, platelets in the blood decrease. In particular, since blood clots form in areas where blood clots do not normally occur, such as vein passages (venous sinuses) or visceral veins of the brain, symptoms such as headache, abdominal pain, shortness of breath, and swelling of the limbs are accompanied. A blood clot can block a blood vessel in an important organ, which can have fatal consequences. It is also called ‘vaccine-induced thrombocytopenic thrombosis (VITT)’ because it occurs as a side effect of vaccination.

The US health and medicine portal ‘WEMD’ reported on this news and reported that ACIP’s recommendations are also a reflection of global trends. Denmark removed the Janssen vaccine from its COVID-19 vaccine program in May. Australia and Greece require young people to be vaccinated against the AstraZeneca vaccine, not the Janssen vaccine. Virus vector vaccine refers to a vaccine in which the antigen gene of coronavirus is injected into another inactivated virus. Both Janssen and AstraZeneca vaccines use adenovirus as a vector.

The risk of dying from TTS after Janssen vaccination is extremely rare. In the general population, it is estimated that there is one death per 2 million people vaccinated. The risk is higher for women between the ages of 30 and 49. The death toll for women in this age group rises to about 2 per million. Experts agree that the Janssen vaccine has saved more lives.

ACIP temporarily halted the use of the Janssen vaccine after the first case of TTS was identified in April, but was lifted 10 days after a new warning was added to the vaccine label to raise awareness of the risk. ACIP’s decision on the 16th was made under the judgment that warning labels alone did not sufficiently reduce the risk of death from TTS. The TTS is more likely to occur in people who have been prescribed heparin, an anti-coagulant drug, and even if doctors are aware of it, the symptoms progressed so quickly that there was no time to take care of it, resulting in additional deaths.

Despite the announcement, the Janssen vaccine is not banned. Patients who are at risk of developing a serious allergic reaction can choose the alternative, and they can vaccinate at any time if they choose the Janssen vaccine even after the risk has been explained. In the Janssen vaccine, inoculation is completed with only one inoculation, and the second inoculation corresponds to a booster shot (additional inoculation).

In the United States, about 17 million doses of Yansin vaccine have been administered so far, and 900,000 doses of the second dose, equivalent to a booster dose, have been received. By the end of August, there were 54 cases of thrombocytopenic syndrome (TTS) in the United States after Janssen vaccination, and nearly half were women aged 30-49 years. Nine people have died from TTS since Janssen vaccination.

By Han Gun-pil, reporter [email protected]

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