------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------

They find a genetic predisposing factor to severe covid-19

The immunity of T cells is one of the mechanisms used by the human body to fight viral infections. In fact, the starting point for the development of cellular immunity is the presentation of virus peptides on the surface of infected cells. It is then that the activation of the T lymphocytes, which begin to eliminate the ‘diseased’ cells.

Researchers from the National Research University of Russia have detailed how the ability to give this type of immune response to SARS-CoV-2 it is largely determined by genetics. In human cells, those responsible are the human leukocyte antigen class I (HLA-I) molecules. The set of six of these molecules is unique in each human being and is inherited from the parents.

“The HLA-I genotype is an important factor for the immune response to any type of viral infection. In our work we show that individuals with specific HLA genotypes are more predisposed to have covid-19 grave. In the same way, there are some ‘strong’ genotypes that are rarely associated with a serious course of the disease ”, he explains to SINC Stepan Nersisyan, one of the authors of the work, published in Frontiers in Immunology.

Individuals with specific HLA genotypes are more predisposed to having severe COVID-19.

Using machine learning (machine learning), the team built a model that provides a comprehensive assessment of the potential potency of the T-cell immune response to COVID-19: whether the allele pool [versiones del gen] HLA-I allows efficient presentation of SARS-CoV-2 virus peptides, those individuals received a low risk score, while those with less presentation ability received higher risk scores.

To validate the model, the genotypes of more than 100 patients who had suffered covid-19 and of more than 400 healthy people were analyzed as a control group. The experts found that the simulated risk score is “very effective in predicting the severity of the disease.”

The risk score suggested by the researchers (vertical axis) is considerably higher in the group of patients suffering from severe COVID-19 (sample of patients from Moscow). / S. Nersisyan et al

In addition to analyzing the Moscow population, the researchers used their model on a sample of patients at the Ramón y Cajal Hospital in Madrid (Spain). “The high precision of the prediction was also confirmed in this independent sample: the risk score of patients with severe covid-19 was significantly higher than in patients with moderate and mild cases of the disease,” they point out.

Other applications of this model

In addition to the correlations discovered between the genotype and the severity of this disease, this new approach may help the evaluation of how a certain mutation of the covid-19 would affect the development of the immunity of T cells against the virus, say the researchers .

“For example, we will be able to detect groups of patients in whom infection with new strains of SARS-CoV-2 can lead to more serious forms of the disease,” he emphasizes. Alexander Tonevitsky, another of the authors.

“Knowledge of people with the HLA genotype at risk could prioritize this group for vaccination”

For his part, Stepan Nersisyan adds that, in the context of a possible shortage of vaccines, “knowledge of people with the HLA genotype at risk could prioritize this group for vaccination.” “Finally, knowing your own risk group can motivate people to maintain a more responsible social distance, to wear a mask and to do other things to be safer,” concludes Nersisyan.

Referencia: Maxim Shkurnikov, Stepan Nersisyan, Tatjana Jankevic, Alexei Galatenko, Ivan Gordeev, Valery Vechorko and Alexander Tonevitsky. ‘Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19’. Front. Immunol., 23 February 2021 |

Source: SINC

Rights: Creative Commons.


Source: Vozpópuli by www.vozpopuli.com.

*The article has been translated based on the content of Vozpópuli by www.vozpopuli.com. If there is any problem regarding the content, copyright, please leave a report below the article. We will try to process as quickly as possible to protect the rights of the author. Thank you very much!

*We just want readers to access information more quickly and easily with other multilingual content, instead of information only available in a certain language.

*We always respect the copyright of the content of the author and always include the original link of the source article.If the author disagrees, just leave the report below the article, the article will be edited or deleted at the request of the author. Thanks very much! Best regards!