The researchers created small human brains with Parkinson’s disease – Human – Science and Technology in the laboratory

For the first time, Singaporean scientists have been able to create small human brains in the laboratory that mimic the main pathological symptoms of Parkinson’s disease.

As the server writes Science Daily, it is also the first case of laboratory – generated Lewy bodies – abnormal aggregations of proteins in nerve cells. Researchers thus have the opportunity to better understand this incurable neurodegenerative disease and what causes it.

“Modeling Parkinson’s disease in animals is difficult because they do not progressively and selectively lose neurons that produce the neurotransmitter dopamine, a major feature of Parkinson’s disease,” said study co-author Ng Huck Hui of the Singapore Institute of Genetics.

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“Another problem is that laboratory mice do not develop the characteristic clusters of proteins known as Lewy bodies, which often occur in the brain cells of people with Parkinson’s disease, and the type of progressive dementia known as Lewy body dementia,” added Ng Huck Hui.

The scientific team therefore turned to small imitations of human brains that he had previously created. “They are basically three-dimensional, multicellular, tissue constructs in a test tube that mimic the human midbrain (mesencephalon),” explained study lead author Junghyun Jo.

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These small organoids – laboratory mimics of organs – grew from human stem cells into a cluster of neurons and other brain cells.

“For the first time, these experiments mimicked the characteristics of Parkinson’s disease that only occur in human patients,” said Hyunsoo Shawn Je of Singapore’s Duke-NUS School of Medicine.

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Researchers do not yet know exactly what causes Parkinson’s disease, but they have nevertheless succeeded in inducing it in the laboratory. This is because they first altered the DNA of stem cells so that they mimic the known genetic risk factors and the preconditions for its emergence. Thus, they were able to grow organoids with Lewy bodies as well as with the selective loss of dopamine-producing neurons.

According to the study’s authors, this discovery provides not only important insights, but also a “humanized” model of the disease on which potential drugs for Parkinson’s disease and dementia can be tested.


Source: Pravda.sk – Veda a technika by vat.pravda.sk.

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