The combination of drugs can reduce the number of cases of malaria by up to 70 percent – Human – Science and Technology

The combination of several doses of malaria vaccine and preventive use of antimalarials provides approximately 70% protection against severe disease, hospitalization and death from this infection.

This follows from a clinical study of researchers from London School of Hygiene and Tropical Medicine (LSHTM). Vaccination together with antimalarials also provides about 63% protection against infection.

The study involved 6,861 children aged five to 17 months from Mali and Burkina Faso. The authors of the study followed them for three years. They found that children who received three doses of vaccine against the disease and chemoprophylaxis before the period when malaria-carrying mosquitoes multiplied the most were at lower risk of infection and death. These children also received a fourth booster dose before the subsequent rainy season.

The effectiveness of the combined approach was 63 percent higher than the course of preventive treatment alone. Protection against severe progression and hospitalization was 71% and against malaria death 73%, according to a clinical study published in the journal The New England Journal of Medicine.

Malaria, one of the most important infectious diseases in the world, is transmitted to humans by Anopheles mosquitoes. Symptoms include fever, chills, sweating, joint and headaches, vomiting and cramps.

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The disease does not have to be fatal if treated in time. But it kills about 400,000 people every year. A significant proportion of victims are children under the age of five from sub-Saharan Africa.

Among the approximately 2,000 children who received the combination, 624 illnesses, 11 hospitalizations, and three deaths were confirmed. In contrast, 1661 cases of malaria, 37 hospitalizations and 11 deaths were confirmed in the same number of children who received only antimalarials.

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Mosquirix, also called ‘RTS, S’, kills parasites that multiply in the liver, while the antimalarial targets parasites that attack red blood cells in the next reproductive cycle. “It worked better than we thought,” study lead author Brian Greenwood of LSHTM told BBC News. “Hospitalizations have decreased, the number of deaths has decreased in both countries – and we really did not expect that,” he added. He said a new approach to malaria prevention could save millions of lives.

According to the researchers, the vaccine could be given together with antimalarials regularly in the period before the expected occurrence of the disease, similar to influenza. So far, more than 740,000 children from sub-Saharan Africa have received it, and doctors have not seen any serious side effects. The next part of the study should be published next year.


Source: Pravda.sk – Veda a technika by vat.pravda.sk.

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