The cause of the delta of the delta transformation became clear Science

The coronavirus delta variant has become the predominant form of the viral disease worldwide. It infects and spreads more sensitively than other forms of the virus.

Published in Science in the study a mutation has been found in the coronavirus delta variant that substantially increases viral infectivity. This mutation is in the viral nucleocapsid, which contains the infectious genome of the virus.

The mutation is well known, but now its function was further elucidated. It helps the virus to spread its genome more efficiently inside the cell. As a result, the infected cell produces even more new viruses.

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A new discovery was made possible by a clever invention by a Nobel laureate Jennifer Doudna developed with colleagues.

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Doudna and colleagues customize so-called virus-like particles in the laboratory. They have all the structural proteins of the virus and are very similar to the real coronavirus, but they are completely harmless.

These virus-like particles can penetrate cells in the laboratory just like a real virus, so their properties can be monitored.

Researchers loaded a special mrna code into such a doll virus. When this snippet of code enters a cell with a virus, it makes the cell glow under the microscope.

The brighter the cells, the more this mrna code has entered them. This also tells you how effectively the right virus would spread the genuine genome into the cell.

Doll viruses were still slightly tampered with. The researchers modified the r203m mutation already known from the corona delta transformation in their crust. Play viruses with this mutation were clearly more effective infectious agents.

“This single change in the delta-transformed nucleocapsid protein loaded cells ten times more mrna than the original coronavirus,” says Doudna. Science-in leaf.

Next, the researchers repeated the experiment with genuine coronavirus. They tampered with the same r203m mutation into the virus and infected the lung cells with the virus. Infected cells produced 51 times more infectious viruses than the original coronavirus strains.

“A mutation in a delta transformation causes the virus to produce infectious particles more efficiently and therefore spreads better,” explains the first author of the study. Abdullah Syed |.

Source: Tiede by

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