British researchers have identified the process behind atherosclerosis and have shown in animal experiments that a drug commonly used to treat acne can be an effective cure for the disease.
A research team led by scientists from the University of Cambridge and King’s College London discovered that a molecule responsible for atherosclerosis causing inelasticity of blood vessel walls that was previously thought to exist only within cells to repair DNA.
Atherosclerosis can cause cardiovascular disease, high blood pressure, stroke, and dementia. There is currently no effective cure for the disease, which is caused by plaques that harden due to calcium deposits, making the arteries inflexible, blocking the body’s blood supply.
In research supported by the British Heart Foundation, scientists found that poly (ADP-ribose) or PAR, which plays a role in repairing DNA, controls bone-like calcium deposition in blood vessel walls.
In rats with chronic kidney disease, the researchers found that the antibiotic used to treat acne, monocycline, is a cure for atherosclerosis, preventing the accumulation of calcium in the vascular system.
The more than their study was the result of a decade of basic research the researchers published it in the scientific journal Cell Reports.
“Atherosclerosis occurs in everyone as the body ages, accelerates in dialysis patients, in their case even children can suffer from it. So far, we didn’t know what drives this process and how it should be handled, ”the Cambridge University statement quoted Professor Melinda Duer, one of the lead authors of the study.
“This hardening or biomineralization is vital in bone formation, however accumulating in the arteries causes a number of vascular and other diseases. We wanted to know what causes this and why the process is concentrated around collagen and elastin, which make up much of the vessel wall.
“For years, we thought so atherosclerosis is associated with DNA damage and DNA damage is the path taken by a number of factors such as smoking, blood fats turn onExplained Professor Cathy Shanahan, co-author of the study.
By NMR spectroscopy, the researchers showed that when cells are stressed and die, They emit PAR, which is closely related to calcium ions. When activated, PAR begins to release larger calcium droplets that bind to the components that provide the elasticity of the vessel walls, form ordered crystals, and harden, rendering the blood vessels inelastic.
“We never thought it was caused by PAR. It was an accidental discovery, but we continued to study it and led it to a possible therapy, Duer said.
Researchers hope that Patients can begin clinical trials within 12 to 18 months.
Source: Patika Magazin Online by www.patikamagazin.hu.
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