About the first infection with the P.1 virus variant (the so-called “Brazilian” strain) on Tuesday reported by the National Public Health Laboratory (NVSPL). It is reported that the infection was found in the body of a person who returned from abroad.
Five varieties are alarming
Already known or emerging virus variants are divided into three groups: attention-grabbing, disturbing, and having serious consequences (the latter do not yet include any variety).
Option P.1, together with B.1.1.7 (detected in the United Kingdom) and B.1.351 (detected in the Republic of South Africa, PAR) and two detected in the United States, are considered to be of concern.
“P.1 is one of three” classic “strains of concern,” the NVSPL report quotes genomic epidemiologist Dr. Gytis Dudas. – The risk for variety P.1 (‘Brazilian’) is similar to that for B.1.351 (‘South Africa’).
The E484K mutation in both strains, mainly due to the presence of both strains, reduces the efficacy of neutralizing antibodies and increases the risk of infection in strains lacking this mutation or after vaccination with currently registered vaccines.
True, studies show that this effect is slightly weaker in P.1 than in B.1.351. “
First found in Japan
Most of the better-known variants of SARS-CoV-2 are more dangerous than the original (so-called wild-type) virus, in 2019. detected in Wuhan. Because they are 20-50 percent. more contagious, more likely to cause fatal disease, more resistant to vaccines, antibodies acquired after illness or vaccination do not respond well enough, vaccines provide less protection against them, the disease is more difficult to respond to treatment, and it is not always possible to diagnose it properly by conventional methods such as PCR tests.
PAR atmaina people who have been vaccinated or COVID-19 may be more likely to become infected. True, there is no evidence yet that people infected with this strain would get harder.
The “Brazilian” is somewhat reminiscent of the PAR variant – it is also able to infect more people who have been ill more often, and a little more often – and vaccinated people). In both strains, mutations were found at similar sites in the viral spike protein, which helps the virus invade cells in the human body. True, genetic studies show that P.1 originated independently of B.1.351.
By the way, P.1 was first detected in Japan by four people from Brazil, performing routine tests at Haneda Airport near Tokyo. Therefore, this variant of the virus is also called “Japanese” and considered branch of virus line B.1.1.28.
One the study showedthat in the largest city in the Amazon region, Manaus, as many as 42 percent have been samples were found in P.1. Skaičiuojamathat approximately 75% of SARS-CoV-2 infections have occurred since October. population there, a jump in disease was recorded a couple of months later.
The “Brazilian” strain has 17 unique mutations, including three that affect the way the virus attaches to a cell in the human body. One of them, called the D614G, was described in the US as early as the beginning of the pandemic. The mutation came from Europe, there is evidence that strains of the virus with this mutation have spread faster than others.
Another mutation, E484K, is also present A variant of SARS-CoV-2 has been identified in Lithuania. It is so called because it occurs at heading 484 when glutamic acid (E) replaces the amino acid lysine (K) is found in natural proteins. It is at this point that the virus connects to an receptor in the cell called angiotensin converting enzyme (ACE2).
According to researchers, E484K is associated with greater resistance to the vaccine. Variants with this mutation are said to be may escape from naturally occurring or vaccinated immunity (at least one form of monoclonal antibody).
In other words, whether antibodies formed after the disease or after the vaccine at least 10 times weaker fights the virus with this mutation, making it possible to become infected both repeatedly and after vaccination.
Antibodies protect the body from infection by attaching to each viral needle protein on its surface, preventing it from penetrating the cells. If a much larger amount of infection attacks the virus when it changes, the antibodies can no longer attach to exactly all parts of the virus.
Source: 15min.lt – suprasti akimirksniu | RSS by www.15min.lt.
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