Smart contact lenses to diagnose cancer

A team of scientists from the Terasaki Institute for Biomedical Innovation in California, he developed contact lenses that diagnose cancer by detecting cancer chemicals found in tears during the early stages of the disease.

Exosomes, a form of small extracellular vesicles, play a crucial role in tumor metastasis and are therefore being studied as potential biomarkers for cancer diagnosis. However, conventional detection methods and microRNA analyzes are expensive and require tedious pre-treatment and long analysis times. Since tumor-related exosomes have been reported to exist in tears, a research team has developed a particular contact lens that captures these “secret messengers” within our bodies.

The lens was designed with antibody-bound micro-cameras capable of capturing the exosomes found in tears. This antibody-conjugated signaling micro-chamber contact lens (ACSM-CL) can be stained for detection with specific antibodies labeled with nanoparticles for selective visualization.

This offers a potential platform for cancer pre-screening and a supportive diagnostic tool that is easy, quick, sensitive, cost-effective and non-invasive.

“Exosomes are a rich source of markers and biomolecules that can be targeted for different biomedical applications,” said Ali Khademhosseini, Director of TIBI “The methodology our team has developed greatly facilitates our ability to tap into this source.”

At this link you can download the complete study

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Source: Il Blog di Beppe Grillo by

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