Due to their special genetic background, some people live for more than 105 years, Italian researchers have found.
This is the first time that the genome of people living for a very long time has been deciphered in such detail, which can serve as a guide as to why they can live such a long life and how they manage to avoid diseases in old age. “Aging increases the risk of many chronic diseases and conditions. We have studied and compared the genetic potential of people over the age of 105 with younger adults living in the same areas in Italy, ”quoted Paolo Garagnani, an expert at the University of Bologna, on the EurekAlert scientific news portal.
In a study with colleagues and a number of Italian research groups and staff from the Nestlé Research Center in Lausanne, Switzerland. 81 very elderly people, 105 years and over 110 years, were involved. Their results were compared with 36 healthy individuals living in the same region, whose mean age was 68 years.
Information from blood tests and genome sequencing has been compared with previous studies, which examined a total of 333 persons over the age of 333 and around sixty.
Five genetic changes have been identified that are common in the over-105 and over-110 age groups. Inspections found the same in those over a hundred years of age.
According to computer analysis, these are genetic modifications can alter the expression of three different genes, which are of paramount importance for cell health.
One such gene (STK17A) coordinates, for example, the cellular response to DNA damage, promotes programmed cell death, and treats dangerous reactive oxygen species. These processes play an important role in the development of many diseases, such as cancer.
Specialists have also examined naturally occurring mutations in age groups. They found that those over 105 and 110 had lower mutation rates than six out of seven genes, respectively. This may have contributed to that they avoided health problems such as heart disease.
Source: Patika Magazin Online by www.patikamagazin.hu.
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