Peanut allergy: a patch to treat allergy in children under 3 years old

A patch that delivers small amounts of peanut through the skin would show promise for treating children under 3 with allergies.

According to a new study led by the Children’s Hospital of Colorado and published in the New England Journal of Medicine, a skin patch delivering low doses of peanut under the skin, could treat young children from 1 to 3 years old allergic to peanut. ‘peanut.

This experimental patch called Viaskin delivers low doses of peanut under the skin. In a phase 3 trial conducted in the United States, Australia and Europe, 362 toddlers with peanut allergy were tested for their tolerance to peanut protein and then randomly assigned to use either the Viaskin patch or a placebo patch. This patch, placed between the shoulder blades, was changed daily and worn daily for a year.

Two-thirds of children have become desensitized to peanuts

This form of epicutaneous immunotherapy relies on the skin’s immune system to trick the body into tolerating small amounts of allergens. The doses used are lower than those of oral immunotherapies, which reduces the risk of adverse effects. The patch is also easier to get young children to accept than an oral treatment.

Results: Of the 362 children who participated in the clinical trial, 84.8% completed the trial. Children were considered desensitized if they could tolerate the equivalent of about 1 to 4 peanuts after treatment (enough to protect them from accidental exposure).

The efficacy of the treatment was observed in two thirds of the children in the group who received the Viaskin patch compared with one third of the children in the placebo group. A difference significant enough to decide to continue the trials, to determine how long children should wear a patch before being immunized.

Source :Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut AllergyNEJM tomorrow 2023

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