Novalgin • medicine for pain, fever and colic

Novalgin is a medicine that helps relieve severe pain, colic and fever. It is offered as drops, tablets, solutions and suppositories. Read here how Novalgin works and what side effects it has.

Novalgin works very reliably as a pain reliever for severe pain and lowers high fever. Novalgin can also relieve cramps and thereby combat severe abdominal pain. The active ingredient in Novalgin is called metamizole. Novalgin is a prescription drug.

At a glance:

Use of Novalgin

Because of its side effects, Novalgin is only used when other drugs are unsuccessful. The Federal Institute for Drugs advises against treatment with metamizole for mild or moderate pain.

In particular, Novalgin is used for:

  • severe pain after surgery or injury
  • Pain from a tumor
  • Colic
  • high fever that cannot be brought down by other drugs

Novalgin as drops, tablets or infusion

Novalgin is only available with a prescription. Drops with 500 mg / ml, tablets or suppositories are available, which should be dosed according to the intensity of the pain. Doctors can also use Novalgin as an injection. Adults can take up to 4,000 mg Novalgin per day. This corresponds to 40 drops up to four times a day. In the case of film-coated tablets, adults can take two tablets up to four times a day at intervals of six to eight hours, and one for suppositories. Novalgin works after about 30 to 60 minutes, a little faster with an injection than with tablets or drops. In elderly patients or those with impaired kidney function, the dose should be reduced.

Side effects of Novalgin

In very rare cases, serious side effects can occur from taking Novalgin. In some other countries, the approval for the active ingredient was therefore withdrawn. The risk of agranulocytosis occurring is around one case per million people treated. However, the study situation on the incidence is still insufficient. Agranulocytosis lowers the number of certain white blood cells (granulocytes). Typical signs of agranulocytosis are the following symptoms:

  • hoarseness
  • Difficulty swallowing / sore throat
  • fever
  • severe feeling of illness
  • Injuries to the mucous membrane that easily become inflamed

If left untreated, this agranulocytosis can lead to death in severe cases. Therefore, the number of granulocytes should be checked by differential blood count during treatment. However, with targeted treatment of the side effects and immediate discontinuation of the drug, the prognosis is good even if agranulocytosis occurs.

Novalgin can also lower blood pressure. In particular, people who already suffer from low blood pressure or shock are at risk. This lowering of blood pressure can be dangerous even with a very high fever. The risk is particularly high when the drug is administered by injection or infusion. It is therefore recommended to give it as drops, tablets or suppositories. If this is not possible, the infusion should be done slowly and the patient carefully monitored.

Allergic skin reaction to Novalgin

Some people are hypersensitive to Novalgin. This affects up to 1 in 1,000 people. This can lead to reddening of the skin, especially on the face and head. This can also be associated with swelling and itchy wheals. In severe cases, this can lead to allergic shock. Burning and itching of the tongue, palms of the hands and soles of the feet were also observed. If an allergic skin reaction is noticed, treatment with Novalgin should be stopped immediately and a doctor should be consulted!

Other possible side effects are:

Contraindications: In these cases, you must not take Novalgin

Anyone who does not tolerate painkillers well, has a blood count disease or is allergic to pyrazolones should not take Novalgin. Disorders of the bone marrow function also speak against treatment with metamizole. A careful assessment of the benefits and risks is necessary in people with chronic hives, bronchial asthma and hypersensitivity to dyes or preservatives.

Drug interactions

If the following drugs are taken at the same time as Novalgin, undesirable interactions may occur:

  • Ciclosporin (suppresses the body’s defenses)

  • Methotrexate (treatment of cancer and rheumatism)

  • Acetylsalicylic acid (relieves pain and fever, helps with heart problems)

  • Bupropion (treatment for depression)

  • Chlorpromazine (used for mental and emotional disorders)

There can also be interactions with anti-coagulant or diuretic drugs and those for high blood pressure.

Novalgin during pregnancy

There are individual studies on the use of metamizole during pregnancy. It does not appear to have any harmful effects during the first three months of pregnancy. Nevertheless, its use is not recommended. Novalgin must not be used in the last trimester of pregnancy, as it significantly increases the risk of complications for both mother and child.

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Source: Lifeline | Das Gesundheitsportal by

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