Mini – hearts are used to examine heart defects Science


Millimetric

the size of mini-hearts pulses in the medium 60 to 100 times per minute. The heart rate is the same as the heart rate of a small human embryo in the womb, the research team reports scientific journal According to Cell.

Researchers at the University of Michigan cultivated these human mini-hearts from human stem cells. For the first time, mini-hearts have been created with the two vestibules and two chambers of the right budding heart. And they also throb.

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The small organs mimic the heart of a human embryo about 25 days old. They never become real hearts. Even in the smallest, they can help researchers.

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Mini-hearts can reveal how congenital heart defects arise. They can tell why a baby’s heart doesn’t scar if he or she gets a heart attack.

Test cores help when scientists want to understand congenital heart defects. They tell how the heart grows and forms.

That’s what a bioengineer says

Zhen Ma

. He develops heart organs at Syracuse University in New York State and is not involved in research at the University of Michigan.

Various human organs such as the brain, intestines and liver have been grown as mini-organs in culture vessels in laboratories for more than ten years. Of these, the cultivation of the human heart has proved more difficult.

Initially, the researchers experimented with mouse stem cells. The mouse’s mini-heart was pulsated, but its cell looked like a pile of heart cells without a shape, says a stem cell biologist

Aitor Aguirre

Michigan State University In the news service of Science magazine.

He wants the mini-heart to have the chambers of the heart and it throbs because the real heart does that too.

The so-called pluripotent stem cells were initially needed for the heart model. They can form almost any tissue in the body.

In Michigan, researchers used cells to create the three layers of tissue that grow in the walls of the heart chamber.

The researchers then immersed the stem cells in nutrients at different concentrations. After the experiments, a recipe was found in which the cells formed tissues, in much the same way as in the embryo as the heart developed.

Such a heart grown for about a week corresponds in structure to the heart of a 25-day-old embryo. The mini-heart has only one ventricle, which eventually becomes the left ventricle of the adult heart.

The diameter of the mini-core at this stage is only two millimeters. Four different cell types of the heart are already growing in it.

Mini-hearts have been pulsating in the laboratory for more than three months.

“We’ll see right away if this artificial body works, that is, if it’s pulsating,” says the author of the research report.

Sasha Mendjan |

. He is a stem cell biologist at the Institute of Biotechnology of the Austrian Academy of Sciences.

The heartbeat of the mini-hearts has helped to see exactly how the heart is developing. The origin of heart diseases has also been clarified.

Mendjan froze the parts of the mini-hearts in an experiment. He found that fetal cells, which are responsible for maintaining tissue structure, migrated to the damaged areas. They repaired the dead cells.

This would explain how babies ’hearts can regenerate without leaving scars. In adults, the destruction of heart cells always leaves scar tissue.

Next, the mini-hearts are connected to the blood vessels. Researchers want to test how the heart pumps blood or nutrients to different parts of the heart.

Sometimes a maintenance plate might be able to grow the heart of a real adult. However, it can take a decade to get to work.


Source: Tiede by www.tiede.fi.

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