Innovative machine in Switzerland develops new skin for burns

Last month, CUTISS AG, a Swiss clinical life sciences company focusing on skin regenerative medicine and tissue engineering, introduced the world’s first automated machine to produce personalized skin tissue implants for adults and children with severe skin lesions. deep burns. The denovoCast machine, developed in collaboration with the leading Swiss research center CSEM, demonstrates the ability to automate the skin manufacturing process and seeks to revolutionize the currently available treatments for severe skin lesions.

Patients with severe burns can benefit

When patients suffer from catastrophic large and deep burns, the ability to quickly, economically and stably deliver large quantities of skin grafts is essential. The survival of large burns is closely related to how quickly the final closure of the wound is achieved.

Accelerating and scaling up the process of culturing individualized skin grafts can change the data and be vital to saving more lives of patients with severe burns, without burdening patients with healthy skin grafts. Each year, 11 million patients suffer from severe burns and need skin surgery to restore skin function.

Photo: Cutiss.Swiss

EU and US markets for severe burns are estimated at more than $ 2 billion and for burn scars to be estimated at more than $ 5 billion. The current standard of care – self-transplantation – is often inadequate due to lack of donors, produces skin that is very thin and leads to permanent painful, debilitating, deforming scars that often require subsequent corrective surgery.

The denovoCast machine produces a specific type of skin tissue called denovoSkin, a bio-mechanical and personalized dermo-epidermal implant developed by CUTISS. It is an innovative process that involves the development of new skin using the body’s own tissue as a model.

DenovoSkin, which is in clinical trials in the European Union, has unique features that promise to surpass any current medical treatment for large and deep skin lesions, with potential lifesaving and soothing results. It promises to grow with the patient, reduce scarring and drastically reduce the number of follow-up corrective procedures required, especially in children.

The process for the denovoSkin biomechanics has so far been manual, time consuming and required a costly specially sterilized space as well as well-trained staff. The denovoCast machine automates tissue formation in a completely closed process, without the need for any manual intervention. It ensures stable reproductive quality, allows the simultaneous cultivation of multiple skin grafts and is expected to reduce production times by more than 30%.

The denovoCast operating machine will now undergo research-level testing at CUTISS to demonstrate its effectiveness and efficiency in research and clinical settings in accordance with GMP Good Manufacturing Practice.

Photo: © Frank Brüderli

Source:

brightvibes.com/2389/en/innovative-machine-grows-new-skin-for-burn-victims


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