infected with Omicron strain Why is the condition less severe than other breeds?

British medical teacher says COVID-19 is an omicron strain cause less severe disease Due to the different body reactions from other species

January 11, 2022 Channel News AsiaPublished the opinion of “Paul Hunter”, a professor of medicine at the University of East Anglia, England, which explains that Why is it infected with Omicron strain? therefore showing less severe symptoms than other types of covid infections

Hunter said that as soon as the omikron strain was first detected in Botswana and South Africa, two important questions followed: 1. Omikron is more contagious than the previous strain. and 2. Omicron will cause more or less severe disease than existing strains.

It is now clear that How quickly did the omikron spread? and how quickly the number of new infections increased But for the question Are omikrons less harmful than other species? including the question Is it less virulent than other species? It’s still a complicated matter.

Previously, there were studies from South Africa. The results (which are pending investigation) indicate that people infected with omikron are less likely to need hospital treatment. compared to the previous species

The research also indicates that Even after being admitted to the hospital Omicron infected people rarely need oxygen. or need to use a ventilator or have to be treated in the ICU or died

But because South Africa is a country with a young population. Compared to the rest of the world, the lack of research results among older people. or those who are at greater risk of infection Therefore, it may overshadow the true abilities of Omikron.

However, more information has emerged over the past month indicating that what is happening in South Africa is not unusual. because data from most countries in Europe which includes English support the proposal that in general Omikron causes less severe disease than previous strains.

This was most evident in the British outbreak. According to analysts from the British Health Security Agency, Those infected with omikron were only one-third more likely to need to be hospitalized, compared to the Delta species.

Of course, if the number of daily omikron infections is very high, as the UK is facing right now. The number of people who need to be hospitalized will also skyrocket. This was evident in the last few days of 2021, when the number of hospitalized COVID-19 cases increased quite dramatically. But it has not exceeded the number seen in the previous wave of outbreaks. Importantly, there was no increase in the number of patients who needed ventilators.

partial immune evasion

There are a number of factors that might explain that. Why did this happen? The first is to have “immunity”

It may be that the immune both from infection and vaccination are occurring widely in many areas of the world. This is enough to reduce the incidence of severe disease.

For the prevention of infection in the early stages which is in the nose and throat Antibodies, or antibodies, fight the virus’ essential structure, the ‘thorn protein’ that appears to play the most important role.

Mutations found in omikron affect spiny proteins. and tends to impair the ability of the immune system to trap the virus. It also reduces the effectiveness of vaccines. or previous infection to prevent new infections

but for the prevention of more serious infections which is usually in the lungs Other immune responses may play a more important role, such as T cell killers. which is a type of white blood cell It acts to destroy foreign substances, including cells in the body that are infected with the virus.

previous research This has not yet been investigated by scientists, indicating that omikron has a small mutation in the T-cell target. which means Immunization, which has the potential to prevent more severe disease manifestations. still have to move on

This is a weighty explanation that Why does the omikron’s virulence appear to be less than that of other species? For example in England It is estimated that nearly 95% of adults are immune to this mutated virus. through vaccination or infection

mutations and symptoms

naturally Omikron may show less severe symptoms than other species. Even in those without prior immunity, however, it is difficult to determine for sure. There are even some signs that it might be.

First, Omikron has multiple mutations. One of these is the location near the furin junction, which is thought to play a key role in the severity of the disease.

laboratory experiments in which the furin’s separation position was removed. It was found that the virus showed reduced growth in human respiratory cells. and caused less severe disease in laboratory animals.

There is a possibility that the mutation at the site of the furin separation This could explain the reduced intensity of the Omikron.

Several groups of experts are still studying Omikron’s abilities. Some of the pending reports indicate that This virus does not grow very well in lung tissue. But it grows better in the upper respiratory tissue. compared to the previous species

Greater growth in the upper airway It may cause more virus to pass through the nose and mouth. This might help explain in part. Why is Omikron more infectious?

and lung infections instead of the upper respiratory tract It is associated with more severe disease. hence the decreased ability to grow in the lungs of the omikron. Therefore, it may be an important factor in explaining the decrease in violence.

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