If you have the Alzheimer’s disease gene, your risk of severe corona doubles ↑ (Study)

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A specific gene mutation (APOE4) is called the ‘Alzheimer’s disease gene’ because it increases the risk of developing Alzheimer’s disease in the future.

People with this ‘Alzheimer’s disease gene’ are much more likely to end up in intensive care if their symptoms get worse if they become infected with COVID-19, a study has found.

A study from the University of Helsinki in Finland found that people with a specific gene mutation (APOE4) had about twice the risk of getting severe from COVID-19 infection, compared to those without.

People with Alzheimer’s disease genes are more susceptible to severe cases such as COVID-19 infection and small brain hemorrhages. People with this gene are more likely to contract COVID-19 and have a higher risk of developing serious symptoms, such as brain bleeding.

The team studied the link between the mutation and severe COVID-19. They also studied microscopic brain changes in the bodies of people who died from COVID-19 and observed the symptoms of long-term mental exhaustion experienced by some survivors. About a third of Finns carry the APOE4 mutation.

Lead author of the study, Dr. Liisa Myllykangas (consultant neuropathologist) at the University of Helsinki, said: “People with the Alzheimer’s disease gene have twice the risk of developing severe cases requiring intensive care (IC) if they get COVID-19. higher than that,” he said.

According to the research team, Alzheimer’s disease genes can adversely affect the severity of certain ‘long COVID’ symptoms, including attention and concentration deficit disorder.

The research team said, “The common ‘epsilon 4 allele’ of the APOE gene appears to be associated with an increased risk of developing severe COVID-19 in the Finnish population. It could be due to genetic homogeneity.”

The research team made full use of data from the FinnGen Project, which combines genomic data generated from biobank samples with health data collected from the Finnish patient registry.

The study was based on data from 46,000 subjects analyzed. More than 2,600 of those analyzed were diagnosed with COVID-19.

The research team said that additional research is needed, such as analyzing the association between memory impairment and COVID-19 in more people with APOE4. In particular, he emphasized the need for long-term follow-up of patients recovering from COVID-19.

The results of this study were published in the international academic journal ≪Acta Neuropathologica Communications≫ and introduced by the American health media ‘Health Day’.

By Kim Young-seop, staff reporter [email protected]

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