Vaccination against COVID could become periodic, such as flu immunization. According to experts, the antibodies will diminish over time, which is why repeating the anti-COVID vaccine will be necessary. In this case, determining the level of antibodies is essential. How often will we have to repeat the COVID vaccine and how do you check the level of antibodies withheld after immunization?
Repeating the vaccine could have two main reasons. The vaccine may be subject to change due to newly discovered strains. They will need to adapt the vaccine in order to be effective against new variants. The second reason is strictly related to our own body and ability to produce antibodies. The immune response may be limited, and in this circumstance the body will need regular stimulation to produce other antibodies. How often will we have to repeat the COVID vaccine and how can we determine the level of antibodies?
Alexandru Rafila, WHO representative, explains exclusively for Digi24 why it will be necessary to repeat the immunization plan and also how to determine the level of antibodies present in the body.
“It is possible to have vaccination cycles similar to those for the prevention of influenza infection, for two reasons: one reason may be the antigenic variation, the so-called mutations, which can lead to the emergence of new strains and then should every year or two years, maybe, this is an issue we can’t figure out now, but vaccines should keep up with these mutations if they prove to be ineffective.
This is the first eventuality. The second eventuality is related to the persistence of the immune response, ie whether the persistence of the immune response will exist for one year, two years or three years. Depending on this persistence of the immune response after vaccination, there will be opportunities for the administration of this additional dose periodically “, explains Alexandru Rafila.
Determining the level of antibodies is essential to know when you need to get vaccinated again
“As for the serious serological tests that determine the antibodies, they have improved a lot. If initially there were tests that showed the type of antibodies, ie those that appear for the first time, in the first phase – they are called immunoglobulins M (IgM) or immunoglobulins G (IgG), being specific to coronavirus infection, but it was a mix of antibodies – in at the moment we have two elements that matter.
The first is related to the fact that anti-Spike antibodies are now detected, ie against the S protein, even more than that, they are neutralizing antibodies, ie they are exactly those that block portions of the S protein, responsible for attachment to a cell. And we can have – we do not have exactly quantitative tests yet, that is to see an antibody titer, but we have semi-quantitative tests, which show a degree of intensity of the reaction rather than a level, a quantity, of antibodies “, adds Alexandru Rafila .
Source: Doctorul Zilei by www.doctorulzilei.ro.
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