Caffeine reaches its peak in the blood in about 30 to 60 minutes. 1-2 cups of coffee is enough. The amount of caffeine in the blood is halved in 5 to 8 hours.
However, the half-life is individual. It is affected by the absorption and transport of caffeine into the bloodstream and by enzyme-regulated caffeine metabolism.
The invigorating effect of caffeine is also individual. Someone can drink coffee in the pot without refreshing, another half a cup is effective. About a third of us are sensitive to caffeine and another third are moderately sensitive. After all, caffeine works poorly, if at all.
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The difference is related to genetic factors, i.e., individually acting cellular adenosine receptors to which both adenosine and caffeine bind. Adenosine is the brain’s sands of sleep. When it accumulates in nerve cells, it begins to get tired. If caffeine blocks the receptors, falling asleep is prevented and only succeeds when caffeine is broken down in the body.
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As a defendant
Docent of Physiology, University of Helsinki.
Published in Science Journal 8/2021
Source: Tiede by www.tiede.fi.
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