Endocrine disruptors (especially bisphenol A) affect fertility


According to a new French study, postnatal exposure to bisphenol A could adversely affect fertility, but also cause delayed puberty and menstrual cycle disorders.

Endocrine disruptors are substances capable of interfering with our hormonal system. Bisphenol A, bisphenol B … are thus capable of altering various mechanisms, such as communication between certain cells or the development of certain functions of the organism.

Precisely: according to recent work carried out by Inserm, the University Hospital of Lille and the University of Lille, early exposure to endocrine disruptors would harm reproductive functions.

The researchers explain that “in mammals, reproduction is regulated by GnRH neurons, a population of neurons which, during embryonic development, appear in the nose and then migrate to the brain to the hypothalamus. (…) These neurons [contrôlent] all the processes associated with reproductive functions: puberty, the acquisition of secondary sexual characteristics and fertility in adulthood“.

Delayed puberty, disrupted menstrual cycles, impaired fertility …

Thanks to a study of female rats (who were injected daily with bisphenol A for 10 days after birth), scientists found that postnatal exposure to bisphenol A disrupted the integration of neurons into GnRH. within the neural system. The rats thus exhibited delayed puberty and disrupted “menstrual cycles”, with impaired reproductive functions.

Our results raise the idea that early exposure to chemicals in contact with food, such as bisphenol A, may disrupt the onset of puberty and have a lasting impact on reproductive functions.“scientists analyze.

If bisphenol A has been banned in baby bottles and other food containers since 2015, the researchers explain that the risk is still present: “bisphenol A is still present in our environment due to the slow degradation of plastic waste, but also because it is found in food containers purchased before 2015 and which have been stored. With the recycling of waste, the bisphenol A contained in plastics dating from before 2015 could also be found in new products.

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