Effective even with 1/4 of the dose – different

Moderna Vaccine: Effective even with 1/4 dose

This indication may prove valuable in order to accelerate vaccination of as much of the world’s population as possible.

A by a much smaller dose of the Moderna vaccine, from the one that is given all over the world, seems to be enough to produce antibodies lasting months after vaccination, giving experts hope that they will thus address the problem of dosing shortages, especially in developing countries.

The two doses of the Moderna vaccine with the ¼ of the quantity currently offered adequate protective antibodies and T cells to fight the coronavirus, according to the first results of research in 35 volunteers. This indication may prove valuable in order to accelerate vaccination of as many of the world’s population as possible.

In the early trials of the Moderna vaccine, participants received three different doses, of 25, 100 and 250 micrograms, in order to determine best practice. The high dose turned out to be highly toxic, while the lower dose provided a weaker immune response, according to a publication in the scientific journal Nature.

After vaccine testing, the 100 micrograms received the “green light” as an appropriate dose for vaccination with two doses of Moderna mRNA vaccine.

The lower the dose, the better

The researchers today tested the antibodies in the blood of 35 volunteers who received the lowest dose of 35 micrograms, in two doses, 28 days apart, the first from the second. Six months after the second dose, almost all participants had antibodies capable of preventing the virus from infecting cells in the body.

In preliminary investigation published last Monday, July 5, it seems that the blood of the volunteers contained a series of T cells, capable of destroying the coronavirus-infected cells, as well as helper cells that contribute to the body’s defense in general.

The levels of antibodies and T cells were comparable to those found in the blood of people who recovered from the coronavirus.

«It is remarkable and very promising that one can detect an immune response for such a long timeSays Daniela Weiskopf, a California infectious disease specialist who co-authored the new study.

However, the scientists signing the research argue that it is better to give half a dose to an unvaccinated today than a whole one a year. As they say, this. Dose extension (at a lower dosage) may prove to be “a way of promoting vaccination equality”.

Source: protothema.gr

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