Semaglutide, also known under the trade names Ribelsus and Osempik, is prescribed for type 2 diabetes. Semaglutide enhances insulin synthesis and stimulates the growth of the beta cells in the pancreas that produce it. Insulin causes the tissues to absorb glucose from the blood, so that Semaglutide causes the blood glucose to drop. At the same time, Semaglutide inhibits the activity of the hormone glucagon. Glucagon causes liver cells to break down stored glycogen, a polysaccharide made up of glucose. The resulting glucose enters the bloodstream, but if Semaglutide inhibits the work of glucagon, then again less glucose will appear.
However, the effect of Semaglutide is seen not only in hormones and glucose. It also suppresses appetite, slows down the digestion of food, and helps reduce body fat. As a result, body weight should decrease. Indeed, in recent years, there have been several works that have said that Semaglutide helps to lose weight. But for the time being, this was only observed as a concomitant effect.
Employees of the University of Liverpool, University College London and a number of other scientific centers decided to purposefully and in accordance with all the rules to check how Semaglutide acts on excess weight. The study involved nearly two thousand overweight and obese people. They were given either Semaglutide or a placebo once a week for almost a year and a half for comparison. In addition, they were told once a month about how to switch to a healthier diet and encouraged to be physically active.
In an article in The New England Journal of Medicine it is said that those who received the placebo ended up losing an average of 2.4% of their total body weight, while those who received Semaglutide lost 14.9%. Portal LiveScience writes that there are other drugs against obesity, but with them you can lose weight only by 7.5%. In addition, these other drugs are usually taken for a short time, no more than a month and a half, and Semaglutide, as it was said, was injected for almost a year and a half. True, it is known for side effects: nausea, diarrhea, constipation, etc., but they are temporary and gradually disappear.
It is possible that Semaglutide can be taken longer. If so, then you can use it to control your weight all your life. However, how safe it is with long-term use will become clear only after additional clinical trials.
Source: Автономная некоммерческая организация "Редакция журнала «Наука и жизнь»" by www.nkj.ru.
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