The preparation from AstraZeneca is less effective against the South African variant, but against the British mutation it offers only slightly lower protection compared to the original version of coronavirus, the doctor warns. He adds that the vaccine also seems to prevent a serious course of the disease in the South African version of the virus.
“This is an important detail“The number of victims in Britain, for example, is very high, thousands of patients with covid-19 are being treated in hospitals and more are dying at home, so reducing the number of those who succumb to the virus and require hospital care should be a key priority. , thus overloading the healthcare system.
If vaccination from AstraZeneca can effectively prevent the severe course of the South African variant of coronavirus, it could help in both of these aspects, says the author of the comment. He declares that a vaccine that prevents serious illness is more than sufficient until the pandemic comes under control.
Vaccines of all types are generally most effective in preventing serious forms of the disease, and their effectiveness in preventing mild and moderate forms is declining, the consultant points out. He explains that vaccination works by preparing the human immune system to meet the virus, so the body can recognize it immediately.
Vaccinated people may have enough neutralizing antibodies in their blood that destroy the virus before it causes the disease, English said. He adds that otherwise the individual develops cellular immunity that can produce these antibodies quickly if necessary.
In addition, vaccination leads the immune system to other reactions, such as the formation of T cells that destroy virus-infected cells, the doctor said. He notes that this immune response can last for a while, so the virus can cause some symptoms, but even so, the result of the vaccination will show in time and prevent a serious course.
“Of course, if we are to completely defeat the virus, we will need a vaccine that prevents infection and transmission“He added that it is not yet clear whether existing vaccines prevent the transmission of the virus through vaccinated individuals, even in the original variant. The third testing phase did not yield clear results, but there is reason for optimism, as AstraZeneca reports talk about reducing incidence of infections by 67%, adds the doctor.
Advent of vaccination platforms
Researchers who have sparked the spread of diseases such as SARS, MERS and Ebola have been working for more than a decade on so-called platforms, systems that will allow rapid vaccination, says English. He explains that in the past, vaccines have been developed in a “single preparation, single disease” style, so scientists have always developed a new vaccine with the advent of new viruses.
Traditional vaccine preparation has involved culturing the pathogen and then introducing a small amount of neutralized virus or bacteria into the body of a patient whose immune system responds to surface antigens to develop antibodies to avert the disease, the doctor said. He adds that vaccination platforms allow scientists to identify the genes of a pathogen and then insert the genes of that part of the antigen against which the human body needs to make antibodies.
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Once such a platform exists, it is easy to quickly and easily insert different genetic material into it, which allows much faster development of vaccines against different variants of the disease, says the consultant. He added that as a result, the development of vaccines against new types of SARS-CoV-2 virus should be relatively easy, and if they were treated by health regulators similarly to the annually amended influenza vaccines, it should be a relatively smooth process.
“In the future, we could even have a single injection each year to protect us from the new SARS-CoV-2 and flu variantsHe believes that future vaccines against new variants of coronavirus will help further reduce the number of cases by suppressing its transmission, eventually squeezing the reproductive number below one, at which point the disease will begin to disappear.
Although existing vaccines are not perfect against all variants of coronavirus, we need to proceed quickly and vaccinate as many people as possible to reduce the serious course of covid-19 and the number of deaths from it, the doctor said. He adds that at a time when there will be fewer hospitalizations and casualties, it will be possible to focus on suppressing virus transmission and mild to moderate cases.
Source: EuroZprávy.cz by eurozpravy.cz.
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