Studies have shown that intestinal bacteria can affect the severity of the novel coronavirus infection (Corona 19) and the intensity of the immune system response.
Here, it has been shown that an imbalance in the intestinal microbiome (microorganism) can cause persistent symptoms of inflammation associated with the corona.
A research team at the Institute of Digestive Diseases at the Chinese University of Hong Kong analyzed blood and stool samples from 100 corona patients and 78 uninfected adults who participated in a microbiome study before the corona 19 epidemic.
The researchers found that in 274 stool samples, the gut microbiome was significantly different between patients with COVID-19 and non-infected people, regardless of whether they were given drugs, including antibiotics.
People with COVID-19, for example, had fewer types of bacteria that could affect the immune system response than those who were not infected. This decrease in the number of bacteria was associated with the severity of the infection.
Moreover, it was found that the number of these bacteria remained low until 30 days after the virus was removed by patients infected with COVID-19.
Corona 19 stimulates the immune system to make inflammatory cytokines, and in some cases, this reaction is excessive and can cause widespread tissue damage, septic shock, and organ failure.
Analysis of blood samples revealed that microbiota imbalance in patients with COVID-19 was associated with high levels of inflammatory cytokines and blood markers of tissue damage, such as C-reactive proteins.
Dr. Eungsu Chu of the research team said, “The imbalance of the microbiome in the gut is involved in the severity of Corona 19, and if this imbalance persists even after the coronavirus is removed, it can cause persistent symptoms and multi-organ inflammatory syndrome, like long-term corona syndrome. There is” he said.
“Recovering missing beneficial bacteria can increase immunity against coronavirus and accelerate recovery from disease,” he said. “Managing Corona 19 aims not only to eliminate the virus, but also to restore the gut microbiota. It should be done.”
The findings of this study (Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19) were published in Gut.
Reporter Kwon Soon-il firstname.lastname@example.org
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