An oxidative-antioxidant imbalance in the blood could be an early indicator of Alzheimer’s, a study has found. Researchers at the Canadian National Institutes of Science (INRS) found that oxidative markers known to be involved in Alzheimer’s disease increased five years before the onset of the disease. Therefore, antioxidant intake may pave the way for preventive interventions in Alzheimer’s disease.
Professor Charles Ramasami, who led the study, said: “Considering that people with Alzheimer’s disease have increased oxidative stress, we may be able to modulate the antioxidant system.” For example, it can transport lipids and cholesterol in the blood and modulate antioxidant systems such as apolipoproteins J and D, which play important roles in brain function and Alzheimer’s disease. “Another way is to increase your antioxidant intake through nutrition,” he added.
Unlike the invasive and expensive tests used to diagnose Alzheimer’s disease, the oxidation markers the team found can be detected with a blood test. This indicator is found in extracellular vesicles, nanoparticles that are released by every cell in the body, including the brain.
The team focused specifically on sporadic Alzheimer’s disease. It is the most common form of Alzheimer’s disease, mainly due to the presence of the apolipoprotein gene. By identifying oxidative markers in the blood of people at risk before the onset of Alzheimer’s disease, the researchers emphasized that it could be possible to create ways to slow the onset and reduce the risk.
The study was published in Alzheimer’s and Dementia: Diagnosis, Evaluation, and Disease Monitoring. Original title: ‘Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer’s disease
Reporter Lee Bo-hyun [email protected]
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