The IRONHEART research group of the University of Debrecen (DE) has discovered a new molecule from which a drug can be made for the treatment of cardiovascular diseases, the institution announced on its website.
In Hungary, cardiovascular disease is the leading cause of death, and is also one of the most important risk factors in deteriorating quality of life. That is why the IRONHEART program was primarily aimed at exploring new prevention and treatment options, they wrote.
The research network at the University of Debrecen has established one of the international centers for vascular and cardiovascular diseases. The complexity of the program is indicated by the fact that it also covers the problems of the elderly, very seriously ill people, starting from the vascular diseases of the premature infants.
“Our project is unique because it conducted the basic research along with clinical trials to analyze the relationships. It is also special because, in a unique way in the country, our programs operated geographically side by side, in close proximity, and the theoretical institutes and clinics could thus work together, ”the communication quoted as saying. György Balla academician, university professor, professional project leader.
One of the most important achievements of the four-year IRONHEART program is that of professionals a new molecule (BGP-15) has been found from which a drug can be made in the future. Clinical trials are already underway and the results are convincing, the professor added.
University professor Zoltán Csanádi, head of the arrhythmia sub-program, highlighted: the drug molecule has been shown to be safe in the treatment of cardiac arrhythmias based on human clinical trials, and they hope to be examined soon in the form of heart failure with a relaxation disorder. The IRONHEART program has enriched science with a drug molecule in an area where there was not even an effective drug candidate. This is also a huge value for the University of Debrecen and cardiovascular science, he emphasized.
The research team has also achieved outstanding results improving quality of life in chronic kidney disease, stroke patients, and chronic cardiovascular complications caused by Covid-19.
Oncology was also a sub-program of the IRONHEART program. The vascular system of human tumors aggressively promotes growth and the development of metastases. In this connection, the researchers also studied the destruction of the blood vessels feeding the tumor and the inhibition of vascular development. In the four-year program, modern laboratory procedures and methods have also been developed, which can become a part of everyday routine diagnostics – read in the announcement.
The IRONHEART consortium consisted of 11 research groups, with two academics and nine doctorates from the Hungarian Academy of Sciences leading the sub-programs. The project employed more than 130 professionals and produced about 100 international, high-quality scientific papers.
Professional leaders considered it importanteducation of young people also: young researchers participating in the research and performing excellently will be further employed at the university, they will be provided with the research career model – they said.
Source: Patika Magazin Online by www.patikamagazin.hu.
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